Endocrine Abstracts

Numerous epidemiologic studies have associated hyponatremia with both osteoporosis and bone fractures. Disordered bone metabolism with hyponatremia occurs primarily by direct sodium-sensing mechanisms on osteoclasts that are independent from osmolality. Additional effects may be mediated by arginine vasopressin (AVP) receptors on osteoclasts and osteoblasts. Further, even mild hyponatremia can contribute to neurological dysfunction via gait instability and increased falls, bot...